Accelerating the Development, Assessment, and Access of Treatments. Let's change lives.
From clinical development to regulatory submission, from real-world evidence studies to commercial launch, Lighten delivers the clinical intelligence that drives every critical decision.
EHR-Grounded Clinical Truth. Claims Integration When It Strengthens the Answer.
Generating evidence that reflects clinical reality, at the scale your programs demand.
We start with EHR data for clinical ground truth: confirmed diagnoses, lab values, biomarkers, treatment rationale, disease progression. For many use cases, deep EHR curation alone delivers the clinical depth and longitudinal continuity needed. When complete population coverage is required, we integrate EHR-grounded signals and claims with clinical intelligence.
Built for Every Function That Depends on Clinical Truth
Find the Right Patients. Engage the Right Physicians. Launch with Confidence.
Size markets accurately, engage the physicians actually making the diagnosis, and track launch performance against what's truly happening in clinical practice.
Real-World Evidence That Holds Up to Scrutiny.
Power natural history studies, comparative effectiveness research, burden-of-illness analyses, and payer dossiers with confirmed diagnoses, true treatment exposure, documented outcomes, and the clinical rationale behind every decision.
Design Smarter Trials. Accelerate Enrollment. De-Risk Development.
Ground your site selection and patient finding in clinical notes documentation and surfaces the clinical nuances — biomarker status, prior lines of therapy, disease severity — that claims data simply cannot see.
Case studies
New Frontier in Patient Finding: Scaling EHR Signals to Claims
6x more confirmed patients. 37% higher precision vs. using standard claims criteria.
Customer Story: Patient Finding in Rare Disease
2.5x more confirmed patients in 3 days vs. an entire year of salesforce efforts.
The Same Patients, Completely Different Answers
How integrating EHR with claims changes every conclusion, from market sizing to disease burden.
Regulatory-Grade EHR Curation for Natural History Study
Complete longitudinal patient journeys. Delivered in 6 business days post curation protocol approval.
Regulatory Expectations for RWE Data Curation from EHR
Lighten is designed to meet regulatory expectations from the ground up, since Day 1.